08669281 is referenced by 21 patents and cites 192 patents.

The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.

Title
Prodrugs of fumarates and their use in treating various diseases
Application Number
14/32736
Publication Number
8669281 (B1)
Application Date
September 20, 2013
Publication Date
March 11, 2014
Inventor
Carlos N Sanrame
Lexington
MA, US
Thomas Andrew Wynn
Lexington
MA, US
Christopher P Hencken
Boston
MA, US
Scott Duncan
Bedford
MA, US
Tarek A Zeidan
Watertown
MA, US
Agent
Brian C Trinque
Lathrop & Gage
Assignee
Alkermes Pharma Ireland
IE
IPC
C07D 207/40
A61K 31/40
A01N 43/36
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