Retinoid-liposomes for enhancing modulation of HSP47 expression United States Patent 08664376

08664376 is referenced by 6 patents and cites 60 patents.

What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1—2 (SEQ ID NOS: 60 and 127), SERPINH1—45a (SEQ ID NOS: 98 and 165), and SERPINH1—51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.

Title
Retinoid-liposomes for enhancing modulation of HSP47 expression
Application Number
13/492639
Publication Number
8664376 (B2)
Application Date
June 8, 2012
Publication Date
March 4, 2014
Inventor
Yun Liu
San Diego
CA, US
Wenbin Ying
San Diego
CA, US
Kenjiro Minomi
Osaka
JP
Igor Mett
Rehovot
IL
Hagar Kalinski
Rishon Le-Zion
IL
Sharon Avkin Nahum
Nes Ziona
IL
Elena Feinstein
Rehovot
IL
Yasunobu Tanaka
Osaka
JP
Violetta Akopian
Oceanside
CA, US
Loren A Perelman
Oakland
CA, US
Mohammad Ahmadian
Carlsbad
CA, US
Richard P Witte
San Diego
CA, US
Joseph E Payne
Oceanside
CA, US
Victor Knopov
Oceanside
CA, US
Yoshiro Niitsu
Hokkaido
JP
Agent
Baker & Hostetler
Assignee
Nitto Denko Corporation
JP
IPC
C07H 21/04
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Citations: 6

  1. Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier. Nitto Denko Corporation, Baker & Hostetler, October 4, 2016: US09456984 (4 worldwide citation)
  2. Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu, Zheng Hou, John A Gaudette, Priya Karmali, Sridhar C Nagarajan: Retinoid-lipid drug carrier. Nitto Denko Corporation, Baker & Hostetler, February 5, 2019: US10196637
  3. Yoshiro Niitsu, Victor Knopov, Joseph E Payne, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu: Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier. Nitto Denko Corporation, Baker & Hostetler, February 5, 2019: US10195145
  4. Yoshiro Niitsu, Joseph E Payne, John A Gaudette, Zheng Hou, Victor Knopov, Richard P Witte, Mohammad Ahmadian, Loren A Perelman, Yasunobu Tanaka, Violetta Akopian: Compounds for targeting drug delivery and enhancing siRNA activity. Nitto Denko Corporation, Baker & Hostetler, October 16, 2018: US10100004
  5. Kenjirou Minomi, Jihua Liu, Li Wang, Bharat Majeti, Roger Adami, Wenbin Ying: Methods and compositions for treating malignant tumors associated with KRAS mutation. Nitto Denko Corporation, Eckman Law Group, February 28, 2017: US09580710
  6. Joseph E Payne, John A Gaudette, Zheng Hou, Mohammad Ahmadian, Lei Yu, Victor Knopov, Violetta Akopian, Priya Karmali, Richard P Witte, Neda Safarzadeh, Wenbin Ying, Jun Zhang: Lipids for therapeutic agent delivery formulations. Nitto Denko Corporation, Baker & Hostetler, April 12, 2016: US09308267

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