08574615 is referenced by 14 patents and cites 1556 patents.

According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.

Title
Medical devices having nanoporous coatings for controlled therapeutic agent delivery
Application Number
12/787209
Publication Number
8574615 (B2)
Application Date
May 25, 2010
Publication Date
November 5, 2013
Inventor
Michael N Helmus
Worcester
MA, US
Yixin Xu
Newton
MA, US
Barron Tenney
Haverhill
MA, US
Agent
Fish & Richardson P C
Assignee
Boston Scientific Scimed
MN, US
IPC
A61F 2/02
View Original Source