08557231 is referenced by 52 patents and cites 40 patents.

Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

Title
Biodegradable poly(beta-amino esters) and uses thereof
Application Number
11/99886
Publication Number
8557231 (B2)
Application Date
April 6, 2005
Publication Date
October 15, 2013
Inventor
Daniel G Anderson
Framingham
MA, US
Mansoor M Amiji
Attleboro
MA, US
David Putnam
Cambridge
MA, US
David M Lynn
Somerville
MA, US
Robert S Langer
Newton
MA, US
Agent
C Hunter Baker
Wolf Greenfield & Sacks P C
Assignee
Massachusetts Institute of Technology
MA, US
IPC
C08G 69/08
A61K 31/765
A61K 31/785
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