08551480 is referenced by 24 patents and cites 84 patents.

The present invention concerns methods and compositions for forming immunotoxin complexes having a high efficacy and low systemic toxicity. In preferred embodiments, the toxin moiety is a ranpirnase (Rap), such as Rap(Q). In more preferred embodiments, the immunotoxin is made using dock-and-lock (DNL) technology. The immunotoxin exhibits improved pharmacokinetics, with a longer serum half-life and significantly greater efficacy compared to toxin alone, antibody alone, unconjugated toxin plus antibody or even other types of toxin-antibody constructs. In a most preferred embodiment the construct comprises an anti-Trop-2 antibody conjugated to Rap, although other combinations of antibodies, antibody fragments and toxins may be used to form the subject immunotoxins. The immunotoxins are of use to treat a variety of diseases, such as cancer, autoimmune disease or immune dysfunction.

Title
Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity
Application Number
12/871345
Publication Number
8551480 (B2)
Application Date
August 30, 2010
Publication Date
October 8, 2013
Inventor
Edmund A Rossi
Woodland Park
NJ, US
David M Goldenberg
Mendham
NJ, US
Chien Hsing Chang
Downingtown
PA, US
Agent
Richard A Nakashima
Assignee
IBC Pharmaceuticals
NJ, US
IPC
C07K 16/28
C07K 14/46
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