08535702 is referenced by 32 patents and cites 36 patents.

The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

Title
Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
Application Number
11/48616
Publication Number
8535702 (B2)
Application Date
February 1, 2005
Publication Date
September 17, 2013
Inventor
Michael N Helmus
Worcester
MA, US
Shrirang V Ranade
Arlington
MA, US
Rudolf Faust
Lexington
MA, US
Marlene C Schwarz
Auburndale
MA, US
Frederick H Strickler
Natick
MA, US
Robert E Richard
Wrentham
MA, US
Agent
David B Bonham
Mayer & Williams PC
Assignee
Boston Scientific Scimed
MN, US
IPC
A61F 2/00
View Original Source