08506966 is referenced by 33 patents and cites 11 patents.

An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence of high serum antibody titers and also longer seroconversion and seroprotection. The improvement in immune responses is seen for both influenza A virus and influenza B virus strains, but it is particularly marked for influenza B virus. Moreover, while the existing vaccine provides poor immunity in children after a single dose, the adjuvanted vaccine provides high seroprotection rates against the influenza A virus H3N2 subtype even after a single dose. Furthermore, the adjuvanted vaccine offers significantly better seroprotection against mismatched strains of influenza A virus.

Title
Adjuvanted influenza vaccines for pediatric use
Application Number
12/378929
Publication Number
8506966 (B2)
Application Date
February 20, 2009
Publication Date
August 13, 2013
Inventor
Michele Pellegrini
Castelnuovo Berardenga
IT
Nicola Groth
Buonconvento
IT
Audino Podda
Sovicille
IT
Agent
Otis Littlefield
Helen Lee
Assignee
Novartis
CH
IPC
A61K 45/00
A61K 39/145
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