08486374 is referenced by 39 patents and cites 1082 patents.

A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.

Title
Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
Application Number
12/14088
Publication Number
8486374 (B2)
Application Date
January 14, 2008
Publication Date
July 16, 2013
Inventor
Ella Zlatkis
Rehovot
IL
Rita Keynan
Rehovot
IL
Jorge Danziger
Rishom Lezion
IL
Tal Berman
Rishon LeZiyyon
IL
David Schuz
Moshav Gimzu
IL
Alex Besonov
Rehovot
IL
Doron Friedman
Karmei Yosef
IL
Meir Eini
Ness Ziona
IL
Dov Tamarkin
Maccabim
IL
Agent
Fish & Richardson P C
Assignee
Foamix
IL
IPC
A61K 31/00
A61K 31/135
A61K 31/522
A61K 9/12
A61K 31/57
A61K 31/47
A61K 31/4412
A61K 31/351
A61K 31/355
A61K 31/375
A61K 47/34
A61K 33/00
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