08465752 is referenced by 39 patents and cites 80 patents.

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict medication regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

Title
Treatment of renal hypertension or carotid sinus syndrome with adventitial pharmaceutical sympathetic denervation or neuromodulation
Application Number
12/765720
Publication Number
8465752 (B2)
Application Date
April 22, 2010
Publication Date
June 18, 2013
Inventor
Kirk Patrick Seward
San Francisco
CA, US
Agent
Wilson Sonsini Goodrich & Rosati
Assignee
Mercator Medsystems
CA, US
IPC
A61K 39/02
A61K 39/08
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