08435523 is referenced by 8 patents and cites 88 patents.

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.

Title
Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
Application Number
12/773488
Publication Number
8435523 (B2)
Application Date
May 4, 2010
Publication Date
May 7, 2013
Inventor
Jerry A Hall
Gurnee
IL
Andrea Best
Lake Forest
IL
Sandeep Dutta
Gurnee
IL
Wei Liu
Mundelein
IL
Mark Maginn
Wilburton
GB
Duncan Casson
Royston
GB
John Powell
Cambridgeshire
GB
Agent
McAndrews Held & Malloy
Assignee
Abbott Research
NL
IPC
C07K 16/22
A61K 39/395
View Original Source