Techniques to support low density parity check (LDPC) encoding and decoding are described. In an aspect, LDPC encoding and decoding of packets of varying sizes may be supported with a set of base parity check matrices of different dimensions and a set of lifting values of different powers of two. A base parity check matrix G of dimension mB×nB may be used to encode a packet of kB=nB−mB information bits to obtain a codeword of nB code bits. This base parity check matrix may be “lifted” by a lifting value of L to obtain a lifted parity check matrix H of dimension L·mB×L·nB. The lifted parity check matrix may be used to encode a packet of up to L·kB information bits to obtain a codeword of L·nB code bits. A wide range of packet sizes may be supported with the set of base parity check matrices and the set of lifting values.