A flow control arrangement includes a housing defining one or more openings therein. A valve structure is alignable and misalignable with the one or more openings in the housing. Further included in the flow control arrangement is one or more plugs, one each in each of the one or more openings. Each plug is reducible by one or more of exposure to downhole fluids and applied dissolution fluids. A method for carrying out a series of downhole operations includes running the flow control arrangement to a target depth, carrying out a downhole operation requiring the housing to be radially permeability fluid restricted, reducing the plug, carrying out a downhole operation requiring fluid pressure communication through the one or more openings, and mechanically intervening to close the valve structure thereby rendering the one or more openings of the arrangement radially impermeable.