08399443 is referenced by 28 patents and cites 80 patents.

Sympathetic nerves run through the adventitia surrounding renal arteries and are critical in the modulation of systemic hypertension. Hyperactivity of these nerves can cause renal hypertension, a disease prevalent in 30-40% of the adult population. Hypertension can be treated with neuromodulating agents (such as angiotensin converting enzyme inhibitors, angiotensin II inhibitors, or aldosterone receptor blockers), but requires adherence to strict regimens and often does not reach target blood pressure threshold to reduce risk of major cardiovascular events. A minimally invasive solution is presented here to reduce the activity of the sympathetic nerves surrounding the renal artery by locally delivering neurotoxic or sympathetic nerve-blocking agents into the adventitia. Extended elution of these agents may also be accomplished in order to tailor the therapy to the patient.

Title
Treatment of hypertension by renal vascular delivery of guanethidine
Application Number
12/765708
Publication Number
8399443 (B2)
Application Date
April 22, 2010
Publication Date
March 19, 2013
Inventor
Kirk Patrick Seward
San Francisco
CA, US
Agent
Wilson Sonsini Goodrich & Rosati
Assignee
Mercator Medsystems
CA, US
IPC
A61K 31/33
A01N 43/00
View Original Source