08391582 is referenced by 8 patents and cites 145 patents.

An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

Title
System and method for scanning of probe arrays
Application Number
13/480888
Publication Number
8391582 (B2)
Application Date
May 25, 2012
Publication Date
March 5, 2013
Inventor
Oleinik Ovod Ksenia
Newton
MA, US
Joel M Katz
Stoneham
MA, US
Christopher Miles
Acton
MA, US
Roger DiPaolo
Leominster
MA, US
Eric E McKenzie
Malden
MA, US
David Bradbury
Ipswich
MA, US
Thomas P Regan
Dover
MA, US
Tim J Woolaver
Billerica
MA, US
Albert K Bukys
Lexington
MA, US
David A Stura
North Billerica
MA, US
Herman DeWeerd
Bedford
MA, US
James T Overbeck
Hingham
MA, US
Mark Jones
Reading
MA, US
Eric Schultz
North Andover
MA, US
Patrick J Odoy
Rowley
MA, US
Nathan K Weiner
Upton
MA, US
Agent
Affymetrix
Assignee
Affymetrix
CA, US
IPC
G06K 9/00
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