08252923 is referenced by 10 patents and cites 318 patents.

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

Title
Peptidomimetic protease inhibitors
Application Number
12/231982
Publication Number
8252923 (B2)
Application Date
September 8, 2008
Publication Date
August 28, 2012
Inventor
John Irvin Glass
Indianapolis
IN, US
Deqi Guo
Carmel
IN, US
Ling Jin
Carmel
IN, US
Raymond Samuel Parker III
Doylestown
PA, US
Cristina Garcia Paredes
Madrid
ES
Ivan Collado
Madrid
ES
Yvonne Yee Mai Yip
Indianapolis
IN, US
Q May Wang
Indianapolis
IN, US
Frantz Victor
Indianapolis
IN, US
Mark Joseph Tebbe
Hamburg
DE
Xicheng Sun
Superior
CO, US
Nancy June Snyder
Lizton
IN, US
Jason Eric Lamar
Indianapolis
IN, US
Shu Hui Chen
Carmel
IN, US
Robert Edward Babine
Franklin
MA, US
Agent
Kathryn D Soulier
Jonathan P O Brien
Honigman Miller Schwartz and Cohn
Assignee
Vertex Pharmaceuticals Incorporated
MA, US
IPC
C07C 229/00
C07D 493/14
C07D 207/08
C07D 403/02
C07D 233/32
C07D 417/02
C07D 275/06
C07D 241/08
C07D 265/34
View Original Source