08247532 is referenced by 1 patents and cites 329 patents.

This invention relates to processes and intermediates for the preparation of salts of deuterated, enantiomericallv enriched alpha-amino beta-hydroxy acids of Formula 1 wherein the variables R1,R′1 and R′2 are defined herein, and wherein the process may comprise the steps of forming a salt of a compound of Formula 1, and crystallizing said salt to give a compound of greater than 55% enantiomeric excess.

Title
Deuterated hepatitis C protease inhibitors
Application Number
12/953876
Publication Number
8247532 (B2)
Application Date
November 24, 2010
Publication Date
August 21, 2012
Inventor
Francois Maltais
Tewksbury
MA, US
Raymond E Forslund
Natick
MA, US
Young Chun Jung
Lexington
MA, US
Minzhang Chen
Acton
MA, US
Gerald J Tanoury
Hudson
MA, US
Gregor Zlokarnik
La Jolla
CA, US
Youssef Bennani
Boston
MA, US
Robert B Perni
Marlborough
MA, US
Agent
Jonathan P O Brien
Kathryn D Soulier
Honigman Miller Schwartz and Cohn
Assignee
Vertex Pharmaceuticals Incorporated
MA, US
IPC
A61K 38/04
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