08246958 is referenced by 31 patents and cites 15 patents.

The invention provides methods of treatment using humanized immunoglobulins that specifically bind to alpha-4 integrin. The methods are useful for treatment of asthma, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, transplant rejection, graft versus host disease, tumor metastasis, nephritis, atopic dermatitis, psoriasis, myocardial ischemia, and acute leukocyte mediated lung injury.

Title
Methods of inhibiting alpha-4-dependent interactions with VCAM-1 with anti-VLA-4 antibodies
Application Number
12/175116
Publication Number
8246958 (B2)
Application Date
July 17, 2008
Publication Date
August 21, 2012
Inventor
Ted A Yednock
Fairfax
CA, US
Tarran S Jones
Radlett
GB
Jose Saldanha
Enfield
GB
Olivier J Leger
Hertfordshire
GB
Mary M Bendig
Villanova
PA, US
Agent
Crowell & Moring
Assignee
Elan Pharmaceuticals
CA, US
IPC
C07K 16/28
A61K 39/395
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