08217048 is referenced by 1 patents and cites 376 patents.

The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.

Title
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
Application Number
12/825237
Publication Number
8217048 (B2)
Application Date
June 28, 2010
Publication Date
July 10, 2012
Inventor
John H van Drie
Andover
MA, US
Janos Pitlik
Westborough
MA, US
Shawn D Britt
Andover
MA, US
John J Court
Littleton
MA, US
Robert B Perni
Marlborough
MA, US
Agent
Yang Xu
James F Haley Jr
Ropes & Gray
Assignee
Vertex Pharmaceuticals Incorporated
MA, US
IPC
C07D 241/24
A61K 31/497
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