08206741 is referenced by 16 patents and cites 212 patents.

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic/analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

Title
Pharmaceutical compositions for the coordinated delivery of NSAIDs
Application Number
11/129320
Publication Number
8206741 (B2)
Application Date
May 16, 2005
Publication Date
June 26, 2012
Inventor
John R Plachetka
Chapel Hill
NC, US
Agent
Fulbright & Jaworski L
Assignee
POZEN
NC, US
IPC
A61K 9/52
A61K 9/32
A61K 9/24
A61K 9/22
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