08192760 is referenced by 28 patents and cites 260 patents.

Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.

Title
Methods and compositions for treating tissue using silk proteins
Application Number
11/566643
Publication Number
8192760 (B2)
Application Date
December 4, 2006
Publication Date
June 5, 2012
Inventor
Gene Michal
San Francisco
CA, US
John Stankus
Campbell
CA, US
Mikael Trollsas
San Jose
CA, US
Michael Ngo
San Jose
CA, US
Syed Hossainy
Fremont
CA, US
Agent
Blakely Sokoloff Taylor & Zafman
Randy Shen
Assignee
Abbott Cardiovascular Systems
CA, US
IPC
C08L 89/00
C08G 63/91
A61F 2/00
C07K 17/08
A61K 47/42
A61K 47/48
A61K 35/28
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