08173170 is referenced by 15 patents and cites 25 patents.

An astrocyte-specific drug carrier containing a retinoid derivative and/or a vitamin A analog as a constituent; a drug delivery method with the use of the same; a drug containing the same; and a therapeutic method with the use of the drug. By binding a drug carrier to a retinoid derivative such as vitamin A or a vitamin A analog or encapsulating the same in the drug carrier, a drug for therapeutic use can be delivered specifically to astrocytes. As a result, an astrocyte-related disease can be efficiently and effectively inhibited or prevented while minimizing side effects. As the drug inhibiting the activity or growth of astrocytes, for example, a siRNA against HSP47 which is a collagen-specific molecule chaperone may be encapsulated in the drug carrier. Thus, the secretion of type I to type IV collagens can be inhibited at the same time and, in its turn, fibrosis can be effectively inhibited.

Title
Drug carrier and drug carrier kit for inhibiting fibrosis
Application Number
11/793736
Publication Number
8173170 (B2)
Application Date
December 22, 2005
Publication Date
May 8, 2012
Inventor
Yasushi Sato
Hokkaido
JP
Junji Kato
Hokkaido
JP
Yoshiro Niitsu
Hokkaido
JP
Agent
Knobbe Martens Olson & Bear
Assignee
Nitto Denko Corporation
JP
IPC
C12N 15/11
A61K 31/07
A61K 9/14
A61K 9/127
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