08168389 is referenced by 24 patents and cites 610 patents.

The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.

Title
Fetal cell analysis using sample splitting
Application Number
12/230628
Publication Number
8168389 (B2)
Application Date
September 2, 2008
Publication Date
May 1, 2012
Inventor
Ronald W Davis
Palo Alto
CA, US
Roland Stoughton
The Sea Ranch
CA, US
Mehmet Toner
Wellesley
MA, US
Ravi Kapur
Sharon
MA, US
Daniel Shoemaker
San Diego
CA, US
Agent
Fish & Richardson P C
Assignee
Verinata Health
CA, US
GPB Scientific
VA, US
The General Hospital Corporation
MA, US
IPC
C12Q 1/68
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