08145317 is referenced by 233 patents and cites 584 patents.

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Title
Methods for renal neuromodulation
Application Number
11/368577
Publication Number
8145317 (B2)
Application Date
March 6, 2006
Publication Date
March 27, 2012
Inventor
Mark Gelfand
New York
NY, US
Howard R Levin
Teaneck
NJ, US
Douglas Sutton
Pacifica
CA, US
Mark Deem
Mountain View
CA, US
Hanson Gifford III
Woodside
CA, US
Denise Demarais
Los Gatos
CA, US
Agent
Perkins Coie
Assignee
Ardian
CA, US
IPC
A61K 9/22
A61F 7/00
A61N 1/00
View Original Source