08131371 is referenced by 261 patents and cites 581 patents.

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.

Title
Methods and apparatus for monopolar renal neuromodulation
Application Number
11/403329
Publication Number
8131371 (B2)
Application Date
April 13, 2006
Publication Date
March 6, 2012
Inventor
Nicolas Zadno
Fremont
CA, US
Mark Gelfand
New York
NY, US
Howard R Levin
Teaneck
NJ, US
Mark Deem
Mountain View
CA, US
Hanson Gifford III
Woodside
CA, US
Denise Demarals
Los Gatos
CA, US
Agent
Perkins Coie
Assignee
Ardian
CA, US
IPC
A61N 1/30
A61N 1/00
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