08105631 is referenced by 37 patents and cites 238 patents.

The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

Title
Opioid agonist/antagonist combinations
Application Number
12/785957
Publication Number
8105631 (B2)
Application Date
May 24, 2010
Publication Date
January 31, 2012
Inventor
Robert D Colucci
Newtown
CT, US
Robert F Kaiko
Weston
CT, US
Agent
Davidson Davidson & Kappel
Assignee
Purdue Pharma
CT, US
IPC
A61K 9/48
A61K 9/14
View Original Source