08088928 is referenced by 17 patents and cites 108 patents.

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Title
Sirtuin modulating compounds
Application Number
11/499901
Publication Number
8088928 (B2)
Application Date
August 4, 2006
Publication Date
January 3, 2012
Inventor
David Armistead
Sudbury
MA, US
Thomas Salzmann
Warren
NJ, US
Jeremy S Disch
Natick
MA, US
Pui Yee Ng
Boston
MA, US
Chi B Vu
Arlington
MA, US
Roger Xie
Southborough
MA, US
Jean Bemis
Arlington
MA, US
Jill Milne
Brookline
MA, US
Joseph J Nunes
Andover
MA, US
Agent
Ropes & Gray
Assignee
Sirtris Pharmaceuticals
MA, US
IPC
A61K 31/42
C07D 498/02
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