08071082 is referenced by 25 patents and cites 30 patents.

Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.

Title
End-modified poly(beta-amino esters) and uses thereof
Application Number
11/780754
Publication Number
8071082 (B2)
Application Date
July 20, 2007
Publication Date
December 6, 2011
Inventor
Daniel G Anderson
Sudbury
MA, US
Robert S Langer
Newton
MA, US
Andreas Zumbuehl
Bern
CH
Gregory T Zugates
Cambridge
MA, US
Agent
Robin A Weatherhead
C Hunter Baker
Wolf Greenfield & Sacks P C
Assignee
Massachusetts Institute of Technology
MA, US
IPC
C08F 26/00
C12N 15/11
A61K 48/00
A61K 9/00
A61K 31/765
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