08008032 is referenced by 23 patents and cites 50 patents.

Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the affinity tag can be selectively captured by a capture moiety, wherein the affinity tags do not comprise a magnetic particle; and flowing the sample through a microfluidic device comprising the capture moiety to selectively retain ATL-bound cells. Methods for enriching circulating tumor cells, and devices for enriching specific cells from cellular samples are also disclosed.

Title
Tagged ligands for enrichment of rare analytes from a mixed sample
Application Number
12/37077
Publication Number
8008032 (B2)
Application Date
February 25, 2008
Publication Date
August 30, 2011
Inventor
Helen Barnes
San Diego
CA, US
Allyn Forsyth
San Diego
CA, US
Agent
Wilson Sonsini Goodrich & Rosati
Assignee
Cellective DX Corporation
CA, US
IPC
B01L 3/00
G01N 1/18
G01N 37/00
G01N 33/574
View Original Source