A voice acquisition system for a vehicle includes an interior rearview mirror assembly. The mirror assembly may include a microphone for receiving audio signals within a cabin of the vehicle and generating an output indicative of these audio signals. The microphone may provide sound capture for a hands free cell phone system, an audio recording system and/or an emergency communication system. The system may include a control that is responsive to the output from the microphone and that distinguishes vocal signals from non-vocal signals present in the output. The microphone may provide sound capture for at least one accessory of the equipped vehicle, and the accessory may be responsive to a vocal signal captured by the microphone. The interior rearview mirror assembly may include at least one accessory, such as an antenna, a video device, a security system status indicator, a tire pressure indicator display and/or a loudspeaker.