07996084 is referenced by 3 patents and cites 17 patents.

An implantable medical device (IMD) performs periodic testing of a patient to determine ischemia threshold information. At selected times while the patient is at rest, the IMD increases the pacing rate over time until it receives feedback either from the patient or from an ischemia sensor. The IMD determines the threshold based upon the pacing rate at the time when the feedback was received. The threshold information can be used to adjust the upper pacing rate that can be used during rate adaptive pacing, to determine the effects of drug therapy, and to provide a general indication of the state of coronary artery disease in the patient. The periodic increase of pacing rate to the ischemic zone also provides a preconditioning of the myocardium to allow the patient greater exercise benefit without angina.

Title
Implantable medical device with automatic ischemia threshold determination
Application Number
11/379290
Publication Number
7996084 (B2)
Application Date
April 19, 2006
Publication Date
August 9, 2011
Inventor
Robert J Nehls
Lakeville
MN, US
William J Combs
Minnetonka
MN, US
Steven N Lu
Fridley
MN, US
Todd J Sheldon
North Oaks
MN, US
Lee Stylos
Stillwater
MN, US
Agent
Reed A Duthler
Stephen W Bauer
Assignee
Medtronic
MN, US
IPC
A61N 1/08
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