07948015 is referenced by 184 patents and cites 202 patents.

Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

Title
Methods and apparatus for measuring analytes using large scale FET arrays
Application Number
12/2291
Publication Number
7948015 (B2)
Application Date
December 14, 2007
Publication Date
May 24, 2011
Inventor
James Bustillo
Castro Valley
CA, US
Kim L Johnson
Carlsbad
CA, US
Wolfgang Hinz
New Haven
CT, US
Jonathan M Rothberg
Guilford
CT, US
Agent
Kirk Pastorian
Life Technologies Corporation
Assignee
Life Technologies Corporation
CA, US
IPC
G01N 27/403
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