07943179 is referenced by 1 patents and cites 46 patents.

A drug delivery system comprising pH triggerable particles is described. The pH triggerable particles comprise and agent(s) to be delivered, which is encapsulated in a matrix comprising a pH trigger agent and a polymer. Agents including nucleic acids may be delivered intracellularly using the inventive pH triggerable particles. Upon exposure to an acidic environment such as the endosome or phagosome of a cell, the particles dissolve or disrupt due to protonation or an increase in solubility of the pH triggering agent. Pharmaceutical compositions and methods of preparing and administering these particles are also described. These particles may be particularly useful in genetic vaccination.

Title
pH triggerable polymeric particles
Application Number
11/2542
Publication Number
7943179 (B2)
Application Date
December 2, 2004
Publication Date
May 17, 2011
Inventor
Robert S Langer
Newton
MA, US
Daniel G Anderson
Framingham
MA, US
David M Lynn
Middleton
WI, US
Steven R Little
Somerville
MA, US
Agent
C Hunter Baker
Wolf Greenfield & Sacks P C
Assignee
Massachusetts Institute of Technology
MA, US
IPC
A61K 9/16
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