07939094 is referenced by 18 patents and cites 32 patents.

A method is provided for modulating the rate of release of a therapeutic agent from a release region, which constitutes at least a portion of an implantable or insertable medical device and which controls the rate at which the therapeutic is released from the medical device. The method comprises: (a) providing a release region that comprises (i) a therapeutic agent and (ii) polymer composition comprising two or more immiscible phases; and (b) modulating the rate of release of the therapeutic agent by changing the volume that is occupied by at least one of the immiscible polymer phases relative to the total volume of the release region that is formed. The release region can be, for example, a carrier layer, which comprises the therapeutic agent, or a barrier layer, which is disposed over a region that contains the therapeutic agent. In preferred embodiments, the release region is formed by a process comprising: (a) providing a solution comprising (i) a solvent and (ii) the polymer composition; and (b) forming the release region from the solution by removing the solvent from the solution.

Title
Multiphase polymeric drug release region
Application Number
10/175526
Publication Number
7939094 (B2)
Application Date
June 19, 2002
Publication Date
May 10, 2011
Inventor
Robert E Richard
Wrentham
MA, US
Marlene C Schwarz
Auburndale
MA, US
Agent
Keum J Park
David B Bonham
Mayer & Williams PC
Assignee
Boston Scientific Scimed
MN, US
IPC
A61K 9/14
A61K 47/32
A61F 2/00
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