07910568 is referenced by 39 patents and cites 12 patents.

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Title
Derivatives of 4- or 5-aminosalicylic acid
Application Number
11/915305
Publication Number
7910568 (B2)
Application Date
March 31, 2006
Publication Date
March 22, 2011
Inventor
Stefano Fiorucci
Perugie
IT
Vincenzo Santagada
Cosenza
IT
Anna Sparatore
Milan
IT
Giuseppe Caliendo
Naples
IT
Giuseppe Cirino
Naples
IT
John L Wallace
Cochrane
CA
Agent
Bennett Jones
Assignee
Antibe Therapeutics
CA
IPC
C07D 339/02
A61K 31/67
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