07910561 is referenced by 1 patents and cites 11 patents.

The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention. These substituted naphthyridines have unexpected advantageous properties when compared to other naphthyridines reported in PCT publication WO2003/086394, such unexpected advantageous properties may include increased cellular potency/solubility, greater selectivity, enhanced pharmacokinetic properties, lack of off target activity and so on.

Title
Inhibitors of Akt activity
Application Number
11/792121
Publication Number
7910561 (B2)
Application Date
December 9, 2005
Publication Date
March 22, 2011
Inventor
Peter J Manley
Harleysville
PA, US
Mark T Bilodeau
Lansdale
PA, US
Lida R Tehrani
San Diego
CA, US
Brian A Stearns
San Diego
CA, US
Tony Siu
Brookline
MA, US
Kevin J Rodzinak
Schwenksville
PA, US
Jun Liang
Palo Alto
CA, US
Yiwei Li
Ambler
PA, US
Mark E Layton
Harleysville
PA, US
Essa H Hu
Camarillo
CA, US
Jacob M Hoffman
Lansdale
PA, US
Nicholas D P Cosford
San Diego
CA, US
Brian T Campbell
San Diego
CA, US
Jeannie M Arruda
San Diego
CA, US
Agent
David A Muthard
Matthew A Leff
Assignee
Merck Sharp & Dohme
NJ, US
IPC
C07H 15/00
C07D 491/00
C07D 487/00
C09B 25/00
A61K 31/52
A61K 31/495
A61K 31/50
A61K 31/70
A61K 31/541
A01N 43/42
A01N 43/58
A01N 43/04
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