07901950 is referenced by 33 patents and cites 24 patents.

Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ transplants, surgical trauma and cancer. This invention provides a method for assessing the levels of CEC which vary between different studies using a sensitive enrichment, imaging, and enumberation analysis. CD146 is one of the most specific endothelium-associated cell-surface antigens which can be used in image cytometry. CEC analysis provides an essential tool in prognostic/diagnostic evaluation in the clinic.

Title
Method for assessing disease states by profile analysis of isolated circulating endothelial cells
Application Number
11/701763
Publication Number
7901950 (B2)
Application Date
February 2, 2007
Publication Date
March 8, 2011
Inventor
Leon W M M Terstappen
Huntingdon Valley
PA, US
Galla Chandra Rao
Princeton Junction
NJ, US
Gerald V Doyle
Radnor
PA, US
Mark Carle Connelly
Doylestown
PA, US
Assignee
Veridex
NJ, US
IPC
G01N 1/18
G01N 1/00
G01N 33/00
G01N 33/553
View Original Source