07893086 is referenced by 18 patents and cites 107 patents.

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Title
Sirtuin modulating compounds
Application Number
12/214805
Publication Number
7893086 (B2)
Application Date
June 20, 2008
Publication Date
February 22, 2011
Inventor
Chi B Vu
Arlington
MA, US
Robert B Perni
Marlborough
MA, US
Christopher Oalmann
Watertown
MA, US
Pui Yee Ng
Boston
MA, US
Jeremy S Disch
Natick
MA, US
Jean Bemis
Arlington
MA, US
Agent
Ropes & Gray
Assignee
Sirtris Pharmaceuticals
MA, US
IPC
C07D 417/00
C07D 515/02
C07D 513/02
C07D 491/02
C07D 471/02
A61K 31/38
A61K 31/385
A61K 31/425
A61K 31/44
A01N 43/06
A01N 43/26
A01N 43/78
A01N 43/42
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