07863012 is referenced by 36 patents and cites 31 patents.

The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CellSpotterĀ® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

Title
Analysis of circulating tumor cells, fragments, and debris
Application Number
10/780399
Publication Number
7863012 (B2)
Application Date
February 17, 2004
Publication Date
January 4, 2011
Inventor
Steven Gross
Ambler
PA, US
Shawn Mark O Hara
Ambler
PA, US
Leon W M M Terstappen
Huntingdon Valley
PA, US
Herman Rutner
Hatboro
PA, US
Madeline Repollet
Fort Washington
PA, US
Christopher Larson
Media
PA, US
Galla Chandra Rao
Princeton Junction
NJ, US
Assignee
Veridex
NJ, US
IPC
G01N 33/00
G01N 33/553
G01N 33/574
A01N 1/02
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