07820671 is referenced by 17 patents and cites 315 patents.

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.

Title
Peptidomimetic protease inhibitors
Application Number
10/344112
Publication Number
7820671 (B2)
Application Date
August 31, 2001
Publication Date
October 26, 2010
Inventor
Luc Farmer
Foxborough
MA, US
Robert B Perni
Marlborough
MA, US
Yvonne Yee Mai Yip
Indianapolis
IN, US
Q May Wang
Indianapolis
IN, US
Frantz Victor
Indianapolis
IN, US
Mark Joseph Tebbe
Zionsville
IN, US
Xicheng David Sun
Broumfied
CO, US
Nancy June Snyder
Lizton
IN, US
Raymond Samuel Parker III
Doylestown
PA, US
Jason Eric Lamar
Indianapolis
IN, US
Ling Jin
Indianapolis
IN, US
Deqi Guo
Carmel
IN, US
John Irvin Glass
Germantown
MD, US
Cristina Garcia Paredes
Madrid
ES
Ivan Collado
Madrid
ES
Shu Hui Chen
Thousand Oaks
CA, US
Robert Edward Babine
Carlsbad
CA, US
Agent
Kathryn D Soulier
Jonathan P O Brien
Honigman Miller Schwartz and Cohn
Assignee
Vertex Pharmaceuticals Incorporated
MA, US
IPC
C07D 241/02
A61K 31/497
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