07799767 is referenced by 58 patents and cites 64 patents.

The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.

Title
Cross-linked bioactive hydrogel matrices
Application Number
10/372643
Publication Number
7799767 (B2)
Application Date
February 21, 2003
Publication Date
September 21, 2010
Inventor
Ronald Stewart Hill
Greenville
NC, US
Richard Chris Klann
Washington
NC, US
Francis V Lamberti
Greenville
NC, US
Agent
Womble Carlyle Sandridge & Rice PLLC
Assignee
Pioneer Surgical Orthobiologics
NC, US
IPC
A01N 57/00
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