07741457 is referenced by 106 patents and cites 149 patents.

The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.

Title
6-modified bicyclic nucleic acid analogs
Application Number
12/129154
Publication Number
7741457 (B2)
Application Date
May 29, 2008
Publication Date
June 22, 2010
Inventor
Eric E Swayze
Carlsbad
CA, US
Punit P Seth
San Marcos
CA, US
Agent
Jones Day
Assignee
Isis Pharmaceuticals
CA, US
IPC
C07H 21/00
C07H 19/00
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