07731988 is referenced by 5 patents and cites 223 patents.

The invention provides a multi-polymer hydrogel article having a first polymeric, water-swellable material and a second polymeric material, organized such that a first region substantially comprises the first polymeric, water-swellable material, a second region adjacent the first region comprises a mixture of the first polymeric, water-swellable material and the second polymeric material, and a third region adjacent the second region substantially comprises the second polymeric material. The article exhibits an increasing concentration gradient of the second polymeric material moving from the first region, through the second region, to the third region. The invention also provides methods for forming a multi-polymer hydrogel article by (a) forming a hydrogel structure using a first polymeric, water-swellable material, (b) creating an aerogel structure having a plurality of open pores by dehydrating the hydrogel structure, (c) contacting the aerogel structure with a second polymeric material to incorporate the second polymeric material into at least a portion of the plurality of open pores to form the multi-polymer hydrogel article, and (d) rehydrating the multi-polymer hydrogel article.

Title
Multi-polymer hydrogels
Application Number
11/833549
Publication Number
7731988 (B2)
Application Date
August 3, 2007
Publication Date
June 8, 2010
Inventor
Kai Zhang
Warsaw
IN, US
Brian Thomas
Columbia City
IN, US
Agent
Woods Rogers
Assignee
Zimmer
IN, US
IPC
A61F 2/30
A61F 2/28
A61F 2/02
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