07695902 is referenced by 107 patents and cites 529 patents.

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2′-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics. Also included in the invention are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such a ribonuclease is referred to herein as a dsRNase, wherein “ds” indicates the RNase's specificity for certain double-stranded RNA substrates. The artificial substrates for the dsRNases described herein are useful in preparing affinity matrices for purifying mammalian ribonuclease as well as non-degradative RNA-binding proteins.

Title
Oligoribonucleotides and ribonucleases for cleaving RNA
Application Number
10/78949
Publication Number
7695902 (B2)
Application Date
February 20, 2002
Publication Date
April 13, 2010
Inventor
Stanley T Crooke
Carlsbad
CA, US
Agent
Woodcock Washburn
Assignee
Isis Pharmaceuticals
CA, US
IPC
C12N 5/00
C07H 21/02
C12Q 1/68
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