A staple cartridge for use with a surgical stapling device. The stapling device has an actuator that is selectively actuatable in an axial direction and an anvil that is moveable between open and closed positions. The staple cartridge comprises a plurality of staples and a first plurality of staple drivers. Each staple driver has an upper staple supporting surface for supporting one of the staples such that, when actuated, each staple driver drives the staple into the anvil. The upper staple supporting surface supports staples of different wire diameters in an upright position.