07666854 is referenced by 80 patents and cites 152 patents.

The present disclosure describes bis-modified bicyclic nucleosides and oligomeric compounds that can be prepared comprising at least one of these bis-modified bicyclic nucleosides. More particularly, the bis-modified bicyclic nucleosides have at least one substituent group at the 5′-methylene and on the bridge methylene and can be chiral. These bis-modified bicyclic nucleosides are expected to be useful for enhancing one or more property of oligomeric compounds including for example enhancing nuclease resistance.

Title
Bis-modified bicyclic nucleic acid analogs
Application Number
12/331226
Publication Number
7666854 (B2)
Application Date
December 9, 2008
Publication Date
February 23, 2010
Inventor
Eric E Swayze
Carlsbad
CA, US
Punit P Seth
Carlsbad
CA, US
Agent
Jones Day
Assignee
Isis Pharmaceuticals
CA, US
IPC
A61K 31/70
A01N 43/04
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