07635473 is referenced by 19 patents and cites 126 patents.

The present invention provides formulations for maintaining the stability of Aβ binding polypeptides, for example, Aβ antibodies. Exemplary formulations include a tonicity agent such as mannitol and a buffering agent or amino acid such as histidine. Other exemplary formulations include an antioxidant in a sufficient amount as to inhibit by-product formation, for example, the formation of high molecular weight polypeptide aggregates, low molecular weight polypeptide degradation fragments, and mixtures thereof. The formulations of the invention optionally comprise a tonicity agent, such as mannitol, and a buffering agent or amino acid such as histidine. The formulations are suitable for several different routes of administration.

Title
Anti Aβ antibody formulation
Application Number
11/342353
Publication Number
7635473 (B2)
Application Date
January 27, 2006
Publication Date
December 22, 2009
Inventor
Angela Kantor
Pepperell
MA, US
Donna Luisi
North Andover
MA, US
Nicholas W Warne
Andover
MA, US
Agent
Townsend and Townsend and Crew
Assignee
Wyeth
NJ, US
Janssen Alzheimer Immunotherapy
IE
IPC
A61K 39/00
A61K 39/395
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