07632228 is referenced by 410 patents and cites 458 patents.

The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.

Title
Membrane for use with implantable devices
Application Number
10/768889
Publication Number
7632228 (B2)
Application Date
January 29, 2004
Publication Date
December 15, 2009
Inventor
Mark A Tapsak
San Diego
CA, US
Mark C Shults
Madison
WI, US
James H Brauker
San Diego
CA, US
Agent
Knobbe Martens Olson & Bear
Assignee
DexCom
CA, US
IPC
G01N 27/40
A61F 2/02
A61B 5/00
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