07595387 is referenced by 76 patents and cites 271 patents.

Methods and compositions for performing RNA interference with decreased off-target effects are provided The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2′-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.

Title
Modified polynucleotides for reducing off-target effects in RNA interference
Application Number
11/19831
Publication Number
7595387 (B2)
Application Date
December 22, 2004
Publication Date
September 29, 2009
Inventor
Peter S Linsley
Seattle
WA, US
William Marshall
Boulder
CO, US
Anastasia Khvorova
Boulder
CO, US
Angela Reynolds
Conifer
CO, US
Devin Leake
Denver
CO, US
Agent
Scott D Locke Esq
Kalow & Springut
Assignee
Merck & Co
NJ, US
Dharmacon
CO, US
IPC
C07H 21/04
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