07582618 is referenced by 23 patents and cites 366 patents.

The 3′-L-valine ester of β-D-2′-C-methyl-ribofuranosyl cytidine provides superior results against flaviviruses and pestiviruses, including hepatitis C virus. Based on this discovery, compounds, compositions, methods and uses are provided for the treatment of flaviviridae, including HCV, that include the administration of an effective amount of val-mCyd or its salt, ester, prodrug or derivative, optionally in a pharmaceutically acceptable carrier. In an alternative embodiment, val-mCyd is used to treat any virus that replicates through an RNA-dependent RNA polymerase.

Title
2′-C-methyl-3′-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
Application Number
11/516928
Publication Number
7582618 (B2)
Application Date
September 6, 2006
Publication Date
September 1, 2009
Inventor
Gilles Gosselin
Montpellier
FR
Paolo LaColla
Capoterra
IT
Jean Pierre Sommadossi
Cambridge
MA, US
Agent
Jones Day
Assignee
L Universite Montpellier II
FR
Centre National de la Recherche Scientifique
FR
University of Cagliari
IT
Idenix Pharmaceuticals
MA, US
IPC
A61K 31/70
A01N 43/04
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