07569686 is referenced by 91 patents and cites 132 patents.

The present invention provides compounds and methods of using them for preparing bicyclic nucleosides. The bicyclic nucleosides are useful for preparing chemically modified oligomeric compounds. Oligomeric compounds comprising these bicyclic nucleosides have enhanced properties such as increased nuclease resistance.

Title
Compounds and methods for synthesis of bicyclic nucleic acid analogs
Application Number
11/747042
Publication Number
7569686 (B1)
Application Date
May 10, 2007
Publication Date
August 4, 2009
Inventor
Eric E Swayze
Carlsbad
CA, US
Thazha P Prakash
Carlsbad
CA, US
Charles Allerson
San Diego
CA, US
Michael T Migawa
Carlsbad
CA, US
Guillermo Vasquez
Oceanside
CA, US
Punit P Seth
San Marcos
CA, US
Jie Xia
Carlsbad
CA, US
Balkrishen Bhat
Carlsbad
CA, US
Agent
Jones Day
Assignee
Isis Pharmaceuticals
CA, US
IPC
C07H 21/00
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